|
KMID : 0605720070130010075
|
|
Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 1 p.75 ~ p.82
|
|
|
Impaired Fasting Glucose in Psychiatric Patients Taking Antipsychotics： Prevalence & Usefulness of Fasting Glucose as a Screening Test of Impaired Glucose Tolerance
|
|
Choi Jin-Hwan
Park Young-Min
Cho Jin-Seok
Jung Sun-Min
Jung Bong-Ju
Byun Won-Tan
|
|
|
Abstract
|
|
|
Objectives : The aims of this study were to examine the prevalence of impaired fasting glucose, to analyze the correlation of fasting glucose level with 2-hour glucose level after oral glucose loading, and to clarify the usefulness of the fasting glucose test as screening in the patients who are taking antipsychiotic medications.
Methods : We examined the fasting glucose level and 2 hour glucose level after loading 75g of glucose in 96 hospitalized psychiatric patients who had been taking the same medications for at least 2 months. We divided the subjects into 2 groups, impaired fasting glucose and normal fasting glucose group, based on American Diabetes Association criteria proposed in 2004, and compared the demographical and clinical characteristics between the two groups. The subjects with preexisting diabetes mellitus were excluded.
Results : Among 96 subjects, impaired fasting glucose group were 22(22.9%), 10 of them(45.5%) had impaired glucose tolerance, and the rest 12(54.5%) were normal in oral glucose t lerance test. In the normal fasting glucose group of 74 subjects, 52(70.3%) were normal, and 22(29.7%) had impaired glucose tolerance but normal fasting glucose. There was a positive correlation between fasting glucose levels and 2-hour glucose levels after oral glucose loading but the correlation was not strong(Spearman’s R=0.265, p＜0.01). There were no significant differences in fasting and 2-hour glucose levels between typical and atypical antipsychotics groups.
Conclusion : Fasting glucose test could not reflect the cardiovascular risk well in patients who are taking antipsychotics, thus it would not be appropriate to use this as screening test
|
|
|
KEYWORD
|
|
|
Antipsychotics, Diabetes mellitus, Hyperglycemia, Screening test, Fasting blood glucose, Oral glucose tolerance test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|